The typical manifestations of chronic inflammation in aging can also be regarded as a chronic disease.
The latest research proves this view through analysis of human samples. But it did not give a way to correct this problem.
As a universal and safe anti-inflammatory molecule, hydrogen is suitable for long-term use in middle-aged and elderly people. Whether it is possible to correct this aging-related inflammatory response, we will wait and see. The easiest way is to measure the level of CXCL9 found in the study to see if hydrogen therapy can change this molecule and other aging-related indicators. A new type of age "clock" can assess chronic inflammation to predict whether someone is at risk for age-related diseases such as cardiovascular and neurodegenerative diseases. The "biological clock" measures the "biological age", which can be higher or lower than a person's chronological age in consideration of health conditions.
The Inflammatory Aging Clock (iAge), published in the journal Natural Aging on July 12, 2021, is one of the first tools to use inflammation to assess health.
Other "age clocks" use epigenetic markers, a chemical group that labels a person's DNA when it gets old and transmits it when cells divide.
The researchers who developed iAge hope that because inflammation is treatable, the tool can help doctors determine who will benefit from the intervention — which may extend a person's years of healthy life. Research to further strengthen the immune system is vital, not only for predicting unhealthy aging, but also as a mechanism driven. Aging is based on the idea that as one ages, a person’s body experiences chronic, systemic inflammation, because their cells are damaged and release molecules that trigger inflammation. Eventually it will lead to wear and tear of their tissues and organs. People with a healthy immune system can neutralize this inflammation to some extent, while others will age faster.
In order to develop iAge, a team including David Furman, a systems biologist and Nazish Sayed, a vascular expert at Stanford University in California, analyzed blood samples from 1,001 people aged 8-96 who were part of the "1000 Immunization Project". Investigating how the characteristics of chronic, systemic inflammation change with age.
Researchers used participants’ actual age and health information, combined with a machine learning algorithm, to identify protein markers in the blood that most clearly showed systemic inflammation. They specifically pointed out that the immune signal protein or cytokine CXCL9 is the main contributor. Sayed said that CXCL9, as a key component of iAge, provides a new basis for the motto "Old blood vessels grow old".
After developing iAge, researchers tested iAge by collecting the blood of 19 people who lived to be at least 99 years old and using the tool to calculate their biological age. The average age of these centenarians is 40 years lower than their actual age, which is consistent with the view that people with healthier immune systems tend to live longer.
Click below image to know how to make hydrogen water with ST bottle.
For a long time, scientists have been exploring the idea of using the age clock as an indicator of a person's current health. In this field, research based on epigenetics has shown some promise, but María Mittelbrunn, a molecular biologist at the Autonomous University of Madrid, said that it is complicated to assess a person’s biological age by measuring the epigenetic changes in DNA. of. It is easier to measure inflammation with blood tests, which makes tools like iAge more practical in clinical settings.
Furman hopes that iAge and other inflammation-based age clocks can also achieve personalized treatments.
When studying CXCL9 as a biomarker of systemic inflammation, Furman and his colleagues cultured human endothelial cells that make up blood vessel walls in petri dishes, and artificially aged them by allowing them to divide repeatedly. Researchers have found that high levels of protein can cause cells to enter a dysfunctional state. When the research team suppressed the expression of the gene encoding CXCL9, the cells restored some functions, suggesting that the harmful effects of this protein may be reversible.
Mittelbrunn said that if caught early, "inflammation is one of the curable phenotypes. We have developed amazing anti-inflammatory tools that can be easily targeted." Researchers have known for a long time that salicylic acid (the one that makes aspirin) A raw material), JAK/STAT inhibitors have recently been developed for rheumatoid arthritis and other inflammatory diseases.
It is generally believed that the phenomenon of aging and more than 200 diseases (about 90% of diseases) are closely related to "reactive oxygen species (free radicals)". (The remaining 10% is caused by bacteria, viruses and other pathogens.) It can be said that as long as the antioxidant capacity against free radicals is strong enough, the body will hardly get sick.
According to the work "The Miracle of Antioxidants" by Dr. Leicester Paccar, a pioneer in the study of free radicals in the world, the title page clearly reads: This is an "antioxidant" that prevents cancer, heart disease, stroke, and improves brain vitality and quality of life. "The scientific evidence!" He concluded that:
The most important discovery in the medical profession in the 20th century was to clarify that "antioxidants play a huge role in maintaining health." In the 21st century, the treatment methods that mainly rely on living foreign bodies will evolve into relying on enhancing the antioxidant capacity to fight diseases. treatment. The key to disease prevention and longevity is very simple, which is to "maintain the normal concentration and balance of antioxidants in the body."
Relying on food alone cannot get enough antioxidants. Therefore, health foods are very important. However, there is a problem with the intake of health foods. At the same time, it must be fully and effectively absorbed by the body to function. Therefore, good water rich in hydrogen is also very good. Important, because hydrogen has the characteristics of selective neutralization of toxic free radicals, good permeability, and safety. In addition to being rich in hydrogen, electrolyzed hydrogen water is also rich in ionic minerals, showing negative potential, weakly alkaline, and small clusters of water molecules. , It is easy to fully dissolve the health food and absorb it by the human body. At the same time, it also effectively discharges the old waste from the cell metabolism in time.